What is a known adverse effect of sulfonamides (co-trimoxazole)?

Sulfonamides, including co-trimoxazole, are known to potentially cause kidney damage as an adverse effect. This is primarily due to the risk of crystalluria, which can occur when the drug crystallizes in the renal tubules, leading to obstruction and subsequent kidney injury. Kidney damage can manifest as acute kidney injury or interstitial nephritis, both of which can result from the toxic effects or allergic reactions related to sulfonamides.

In addition to kidney damage, sulfonamides can also cause other side effects such as skin reactions and hematological issues, but the association with kidney toxicity is a significant concern in clinical practice. Understanding the potential for this adverse effect is crucial for pharmacy technicians who may be involved in monitoring patients on these medications.