What is the antidote for opioid toxicity?

The antidote for opioid toxicity is naloxone. It is specifically designed to rapidly reverse the effects of opioids, including respiratory depression, sedation, and hypotension. Naloxone works by competitively binding to the opioid receptors in the brain, thereby displacing opioids and reversing their effects. This rapid action makes naloxone a critical medication in emergency situations where opioid overdose is suspected.

Other options listed do not address opioid toxicity appropriately. Pyridoxine is primarily used for treating vitamin B6 deficiency and certain conditions like seizures in patients with specific metabolic disorders, but it does not have any effects on opioid toxicity. Sodium bicarbonate is used to manage metabolic acidosis but has no role in reversing the effects of opioids. Protamine is an antidote for heparin overdose and does not interact with opioid receptors. Thus, naloxone remains the only effective antidote for opioid toxicity, making it the correct choice.