What is the most frequent side effect of stimulant laxatives?

The most frequent side effect of stimulant laxatives is cramping. Stimulant laxatives work by triggering peristalsis – the waving motion of the intestines that pushes stool through the colon. This mechanism can sometimes lead to increased bowel activity and discomfort, manifesting as abdominal cramping.

Cramping occurs because stimulant laxatives can irritate the lining of the gastrointestinal tract and cause contractions to happen more forcefully than usual, which is why many patients report this sensation after taking such medications.

While nausea, constipation, and diarrhea can occur with the use of stimulant laxatives as well, cramping is the most characteristic and frequently reported side effect due to the way these medications act on the digestive system.