What should be used for the reconstitution of a cytotoxic drug along with a 25G needle?

The appropriate choice for the reconstitution of a cytotoxic drug along with a 25G needle is the needle filter. When handling cytotoxic drugs, which are known for their hazardous nature, the use of a needle filter is critical. This type of filter prevents the entry of any particulate matter, including glass shards or rubber pieces from vials, into the syringe or the patient's system during preparation or administration.

Using a needle filter enhances the safety of the preparation process by ensuring that the cytotoxic solution remains uncontaminated and that potential external contaminants are filtered out. It is designed specifically for use with needles, providing a barrier while allowing the drug to pass through when drawn up or injected.

The other options, such as standard filters or hydrophobic disc filters, do not provide the same level of specific protection and filtration needed for cytotoxic agents as needle filters do. While gas-permeable filters have a different application, they are not suitable for the reconstitution of cytotoxic drugs.