What sterilization method is NOT typically used in preparing ophthalmic products?

Microwave sterilization is not typically used in preparing ophthalmic products due to several critical factors. Ophthalmic preparations require meticulous sterility because they are administered directly to the eyes, an area which is highly sensitive and prone to infections.

Microwave sterilization can create uneven heating, which may not effectively eliminate all microbial life throughout the product. Additionally, there is a risk that certain ingredients used in ophthalmic formulations may be adversely affected by microwave energy, potentially leading to alterations in their efficacy or safety.

For ophthalmic preparations, acceptable sterilization methods typically include filtration, radiation, and gas sterilization. Filtration is a common choice because it allows for the removal of bacteria and particles without applying heat. Radiation is effective at achieving sterilization while maintaining the integrity of heat-sensitive compounds. Gas sterilization is also viable for products that cannot withstand high temperatures while still ensuring sterility.

These attributes make microwave sterilization unsuitable for ophthalmic product preparations, emphasizing the need for methods that maintain both efficacy and safety standards in such delicate formulations.