Which medication is known to have increased absorption when taken with food?

Griseofulvin is the medication known to have increased absorption when taken with food. This is particularly important because the effectiveness of griseofulvin, an antifungal agent used to treat various fungal infections, can be significantly enhanced by the presence of dietary fat. When taken with a high-fat meal, griseofulvin's solubility improves, facilitating better absorption in the gastrointestinal tract. This means that patients are often advised to take griseofulvin with a meal, which can help in maximizing its therapeutic effect.

In contrast, the other medications listed typically do not require or benefit from being taken with food. Metformin is usually taken with meals to reduce gastrointestinal side effects but its absorption isn't significantly enhanced by food. Lisinopril, an antihypertensive medication, can be taken with or without food without affecting its absorption. Alendronate, which is used to treat osteoporosis, requires an empty stomach for optimal absorption and should be taken with plenty of water, as food and other medications can interfere with its effectiveness.