Which of the following is NOT an adverse effect of long-term topical corticosteroid use?

Long-term use of topical corticosteroids can lead to several adverse effects due to their systemic absorption and potent pharmacological activity. Among the options listed, weight loss is not typically an adverse effect associated with long-term use of topical corticosteroids.

Cushingoid syndrome is a well-known complication that may arise from the systemic absorption of corticosteroids, leading to symptoms associated with excessive cortisol levels in the body. Skin thinning is another common adverse effect, particularly with prolonged application, as corticosteroids can inhibit collagen synthesis and alter skin structure. Hypertension can also develop due to fluid retention or other metabolic effects caused by corticosteroids.

In contrast, weight loss is generally not attributed to the use of topical corticosteroids. Instead, these medications are more likely to cause weight gain due to fluid retention and metabolic changes. Therefore, weight loss stands out as an option that does not fit the profile of adverse effects linked to long-term topical corticosteroid use.