Which of the following is the antidote for warfarin toxicity?

The antidote for warfarin toxicity is Vitamin K. Warfarin is an anticoagulant that functions by inhibiting the vitamin K-dependent clotting factors (II, VII, IX, and X) in the liver, thereby preventing the formation of blood clots. When an overdose of warfarin occurs, or when a patient's INR (International Normalized Ratio) is significantly elevated, administering Vitamin K can facilitate the synthesis of clotting factors and counteract the anticoagulation effects.

Distinguishing it from the other options: Protamine sulfate is the antidote for heparin overdose, not warfarin. Calcium chloride is used in cases of hypocalcemia or for various cardiac conditions, and sodium thiosulfate is primarily used in treating cyanide poisoning. Thus, these alternatives are not applicable in addressing warfarin toxicity, reinforcing the necessity of Vitamin K as the correct antidote in this context.