Which of the following medications is known to worsen blood pressure issues?

Sudafed, also known as pseudoephedrine, is a decongestant that can lead to increased blood pressure. It works by constricting blood vessels to reduce swelling and congestion, which is beneficial for relieving nasal symptoms. However, this vasoconstriction can also cause an increase in blood pressure, making it a concern for individuals who already have hypertension or other cardiovascular issues. Therefore, Sudafed is specifically known for worsening blood pressure issues, particularly in sensitive populations.

On the other hand, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can cause fluid retention and may affect blood pressure in certain situations, but it is not primarily known for worsening blood pressure like Sudafed. Amoxicillin is an antibiotic that does not have a direct effect on blood pressure. Metformin is an oral medication for managing type 2 diabetes and is not associated with elevating blood pressure levels. This contextual understanding highlights why Sudafed is the correct choice regarding its impact on blood pressure.