Which of the following medications is known to cause weight gain and hypoglycemia?

Glyburide is a medication commonly used to manage blood sugar levels in individuals with type 2 diabetes. It belongs to a class of drugs known as sulfonylureas, which work by stimulating the pancreas to release more insulin. This increase in insulin can lead to lower blood sugar levels; however, it also has the potential to cause hypoglycemia, especially if a dose is missed, if the patient does not eat sufficiently after taking the medication, or if there is a change in physical activity.

In addition to hypoglycemia, glyburide is often associated with weight gain. This can occur because the increased levels of insulin can promote weight gain by enhancing fat storage, reducing fat breakdown, and increasing hunger. As patients achieve better glycemic control with glyburide, they may also experience increased appetite, which can further contribute to weight gain.

In contrast, the other medications listed have different profiles. Avandia, for example, can cause weight gain, but it primarily has a different mechanism of action related to insulin sensitivity rather than stimulating insulin release. Metformin generally helps with weight management and is unlikely to cause hypoglycemia when used alone. Januvia is typically neutral in terms of weight gain and does not usually cause hyp